![Genes | Free Full-Text | ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development Genes | Free Full-Text | ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development](https://www.mdpi.com/genes/genes-12-00845/article_deploy/html/images/genes-12-00845-g002.png)
Genes | Free Full-Text | ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development
![Genes | Free Full-Text | ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development Genes | Free Full-Text | ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development](https://pub.mdpi-res.com/genes/genes-12-00845/article_deploy/html/images/genes-12-00845-g001.png?1622432698)
Genes | Free Full-Text | ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development
![Novel homozygous ataxia‑telangiectasia (A‑T) mutated gene mutation identified in a Chinese pedigree with A‑T Novel homozygous ataxia‑telangiectasia (A‑T) mutated gene mutation identified in a Chinese pedigree with A‑T](https://www.spandidos-publications.com/article_images/mmr/20/2/MMR-20-02-1655-g05.jpg)
Novel homozygous ataxia‑telangiectasia (A‑T) mutated gene mutation identified in a Chinese pedigree with A‑T
![Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis | Communications Biology Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis | Communications Biology](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs42003-021-01884-x/MediaObjects/42003_2021_1884_Fig1_HTML.png)
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis | Communications Biology
![Cellular functions of the protein kinase ATM and their relevance to human disease | Nature Reviews Molecular Cell Biology Cellular functions of the protein kinase ATM and their relevance to human disease | Nature Reviews Molecular Cell Biology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41580-021-00394-2/MediaObjects/41580_2021_394_Fig1_HTML.png)
Cellular functions of the protein kinase ATM and their relevance to human disease | Nature Reviews Molecular Cell Biology
![Figure 1 from THE IMPORTANCE OF THE DIAGNOSIS OF THE ATM GENE (ATAXIA TELANGIECTASIA MUTATED) IN PATIENTS WITH HEREDITARY PRE- DISPOSITION TO BREAST CANCER; NARRATIVE LITERATURE REVIEW | Semantic Scholar Figure 1 from THE IMPORTANCE OF THE DIAGNOSIS OF THE ATM GENE (ATAXIA TELANGIECTASIA MUTATED) IN PATIENTS WITH HEREDITARY PRE- DISPOSITION TO BREAST CANCER; NARRATIVE LITERATURE REVIEW | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/9b75d26d2666586a1e497fa844f787e348d2ecfd/3-Figure1-1.png)
Figure 1 from THE IMPORTANCE OF THE DIAGNOSIS OF THE ATM GENE (ATAXIA TELANGIECTASIA MUTATED) IN PATIENTS WITH HEREDITARY PRE- DISPOSITION TO BREAST CANCER; NARRATIVE LITERATURE REVIEW | Semantic Scholar
![Frontiers | ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment Frontiers | ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment](https://www.frontiersin.org/files/Articles/563159/fgene-11-00933-HTML-r1/image_m/fgene-11-00933-g007.jpg)
Frontiers | ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment
![The distribution of identified germline mutations in the ATM gene. ATM... | Download Scientific Diagram The distribution of identified germline mutations in the ATM gene. ATM... | Download Scientific Diagram](https://www.researchgate.net/publication/330116432/figure/fig1/AS:961365925691393@1606218906396/The-distribution-of-identified-germline-mutations-in-the-ATM-gene-ATM-comprises-3056.png)
The distribution of identified germline mutations in the ATM gene. ATM... | Download Scientific Diagram
![Figure 2 from THE IMPORTANCE OF THE DIAGNOSIS OF THE ATM GENE (ATAXIA TELANGIECTASIA MUTATED) IN PATIENTS WITH HEREDITARY PRE- DISPOSITION TO BREAST CANCER; NARRATIVE LITERATURE REVIEW | Semantic Scholar Figure 2 from THE IMPORTANCE OF THE DIAGNOSIS OF THE ATM GENE (ATAXIA TELANGIECTASIA MUTATED) IN PATIENTS WITH HEREDITARY PRE- DISPOSITION TO BREAST CANCER; NARRATIVE LITERATURE REVIEW | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/9b75d26d2666586a1e497fa844f787e348d2ecfd/3-Figure2-1.png)
Figure 2 from THE IMPORTANCE OF THE DIAGNOSIS OF THE ATM GENE (ATAXIA TELANGIECTASIA MUTATED) IN PATIENTS WITH HEREDITARY PRE- DISPOSITION TO BREAST CANCER; NARRATIVE LITERATURE REVIEW | Semantic Scholar
![Cellular functions of the protein kinase ATM and their relevance to human disease | Nature Reviews Molecular Cell Biology Cellular functions of the protein kinase ATM and their relevance to human disease | Nature Reviews Molecular Cell Biology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41580-021-00394-2/MediaObjects/41580_2021_394_Fig6_HTML.png)
Cellular functions of the protein kinase ATM and their relevance to human disease | Nature Reviews Molecular Cell Biology
![Scheme of the different roles of ATM. ATM plays different roles both in... | Download Scientific Diagram Scheme of the different roles of ATM. ATM plays different roles both in... | Download Scientific Diagram](https://www.researchgate.net/publication/343899833/figure/fig2/AS:929773618487302@1598686713506/Scheme-of-the-different-roles-of-ATM-ATM-plays-different-roles-both-in-the-nucleus-and.png)
Scheme of the different roles of ATM. ATM plays different roles both in... | Download Scientific Diagram
![Schematic representation of the ATM gene and the variants identified.... | Download Scientific Diagram Schematic representation of the ATM gene and the variants identified.... | Download Scientific Diagram](https://www.researchgate.net/publication/309082960/figure/fig1/AS:416852191793152@1476396717426/Schematic-representation-of-the-ATM-gene-and-the-variants-identified-Top-Representation.png)
Schematic representation of the ATM gene and the variants identified.... | Download Scientific Diagram
![Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence | Radiation Oncology | Full Text Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence | Radiation Oncology | Full Text](https://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1748-717X-2-25/MediaObjects/13014_2007_73_Fig1_HTML.jpg)
Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence | Radiation Oncology | Full Text
![Frontiers | The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin Frontiers | The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin](https://www.frontiersin.org/files/Articles/443988/fonc-09-00193-HTML/image_m/fonc-09-00193-g001.jpg)